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Aerie Reports Positive Data on Ophthalmic Drug Rhopressa Aerie Pharmaceuticals, Inc. AERI reported encouraging six-month top-line safety and efficacy results from the phase III trial, ROCKET 4, on lead product candidate Rhopressa. We note that Aerie is evaluating Rhopressa, a novel once-daily eye drop for its ability to lower intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. The trial is being conducted to provide six-month safety data adequate for regulatory filing in Europe. The safety data observed over the six months were consistent with observations in previous three-month and 12-month phase III clinical trials. The two-arm six month trial enrolled approximately 700 patients. The 90-day efficacy readout evaluating once-daily Rhopressa for non-inferiority to twice-daily timolol showed successful achievement of the 90-day primary efficacy endpoint. This data was released in Oct 2016. The most common adverse event was hyperemia, or eye redness which was reported in approximately 48% of patients, 75% of which was mild. The data from the trial also showed that Rhopressa’s performance at months four, five and six remained within the non-inferiority range compared to timolol at each of the IOP measurement time points, including 8 a.m., 10 a.m., and 4 p.m. at baseline IOPs ranging from above 20 mmHg (millimeters of mercury) to below 25 mmHg, and also from above 20 mmHg to below 27 mmHg. The data will be submitted to regulatory bodies in Europe in the second half of 2018. We remind investors that the data from the trial was not necessary for the NDA submission in the U.S, but was included when the NDA was submitted in Feb 2017 as supportive data.  We note that Aerie outperformed the Zacks classified Medical Drugs industry in the last six months. In fact, the stock gained 14.1% during this period, compared with a loss of 2.8 % for the industry. Apart from Rhopressa, Aerie is evaluating Roclatan, a once-daily, quadruple-action fixed-dose combin

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