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Heartburn drug Motilium should be restricted due to heart deaths, says medicines regulator It was found there have been 342 reports of serious side effects and 57 people known to have died from heart problems while taking domperidone Photo: ALAMY By Rebecca Smith, Medical Editor 8:33PM BST 25 Apr 2014 Follow Around two million people were prescribed Motilium, also known as domperidone, for sickness and nausea symptoms, stomach conditions and heartburn. Now following a review at European level, the drug will be restricted for those with sickness and nausea only. It was found there have been 342 reports of serious side effects and 57 people known to have died from heart problems while taking domperidone. The drug is widely prescribed by GPs for babies with severe reflux and can continue to be used in this way under caution and when the doctor has carefully calculated the dose according to the child's weight and is satisfied they do not have a heart condition, a spokesman for the drugs regulator said. The Medicines and Healthcare Products Regulatory Agency issued the updated advice following the review by the European Medicines Agency. Dr Sarah Branch, deputy director of the MHRA’s Vigilance and Risk Management of Medicines Division, said: “This review looked at the available information in depth. "It concluded that the benefits outweigh the risks of using domperidone when used to treat nausea and vomiting but that there should be restrictions on its use. It should no longer be used for symptoms of abdominal discomfort such as heartburn and feelings of fullness. “There is no need to stop taking your medicine. However, if you have an underlying heart condition or have any other questions, please speak to your doctor or pharmacist at your next routine visit. “If you have experienced any side effects to this medicine you can report these to us at: www.mhra.go

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