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Human Gene Therapy publishes review of randomized clinical trials of gene transfer for heart failure with reduced ejection fraction SAN DIEGO, April 11, 2017 /PRNewswire-USNewswire/ -- Renova™ Therapeutics, a biotechnology company developing gene and peptide therapies for cardiovascular and metabolic diseases, today announced its co-founder's online publication of an article in Human Gene Therapy. The article reviews four published clinical trials using gene transfer in patients with heart failure with reduced ejection fraction (HFrEF). The review finds that, while efficacy varied among the clinical trials, gene transfer was not associated with an increased rate of adverse events, supporting further investigations using this treatment method in the HFrEF patient population. The review, which will be published in the May 2017 print issue of Human Gene Therapy, was co-authored by Dr. H. Kirk Hammond and Dr. William Penny, both Professors of Medicine at the University of California - San Diego and cardiologists at the Veterans Affairs San Diego Healthcare System. Dr. Hammond is a co-founder of Renova Therapeutics and a consultant to the company. (PRNewsfoto/Renova Therapeutics)... The authors reviewed safety and efficacy results of four trials utilizing three gene transfer strategies: intracoronary delivery of adeno-associated virus type 1 encoding sarcoplasmic reticulum Ca2 -ATPase (AAV1.SERCA2a; CUPID 1 and CUPID 2); endocardial injection of a plasmid encoding stromal cell-derived factor-1 (pSDF-;  STOP-HF; and intracoronary delivery of adenovirus-5 encoding human adenylyl cyclase type 6 (Ad5.hAC6). Results of the AC6 clinical trial indicate that, through a one-time administration, AC6 gene transfer safely increased heart function beyond optimal heart failure therapy. This Phase 2 trial was funded by the National Institutes of Health (NIH), the Gene Therapy Resource Program and Renova Therapeutics, via an NIH public-private partnership. "With safety results indistin

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