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Biweekly Xeloda(R) Dosing Regimen is Well Tolerated in Advanced Breast Cancer CHICAGO, June 2 /PRNewswire/ -- Results of the first ever study of biweekly Xeloda(R) (capecitabine) in metastatic breast cancer patients demonstrated that a seven-days-on/seven-days-off (7-on/7-off) dosing regimen was well tolerated, enabling safe delivery of higher daily doses of Xeloda. Standard Xeloda dosing is typically 14 days on and seven days off (14-on/7- off). These data from a Phase I study assessing tolerability of higher doses of Xeloda in patients with measurable metastatic breast cancer were presented today by Dr. Maria Theodoulou, M.D., attending physician, Breast Medicine Service at New York's Memorial Sloan-Kettering Cancer Center at the 43rd Annual American Society of Clinical Oncology in Chicago. The study also demonstrated an acceptable safety profile when using a flat dose of Xeloda at 2000 mg twice daily on a 7-on/7-off schedule (total of 4000 mg/day). "Based on the Norton-Simon mathematical model, in this investigational study we have established that capecitabine can potentially be administered safely and effectively at a dose level higher than historically believed feasible because of this new 7-on/7-off dosing schedule," said Clifford Hudis, M.D., chief of the Breast Cancer Medicine Service at Memorial Sloan-Kettering Cancer Center in New York. "This new dosing regimen for capecitabine will serve as a platform for combination treatment with targeted therapies." Breast cancer is the most common cancer among women, other than skin cancer; according to the American Cancer Society (ACS), about 178,480 women in the United States will be found to have invasive breast cancer in 2007. Breast cancer is the second leading cause of cancer death in women, after lung cancer - about 40,460 women will die from the disease this year. Metastatic breast cancer, or cancer that has spread from the breast to other parts of the body, has an especially poor prognosis, with a five-year

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